Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells
R. Jing, P. Jiao, j. chen, X. Meng, X. Wu, Y. Duan, K. Shang, L. Qian, Y. Huang, J. Liu, T. Huang, J. Jin, W. Chen, X. Zeng, W. Yin, , J. Sun
This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.
bioRxiv · Dec 31, 2020Bioengineering