T. Huang

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

This study quantitatively analyzes plasma proteome changes in vaccinated individuals using a nanoparticle-based proteomic workflow, identifying proteins associated with vaccine response and COVID-19 infection.

Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target

This study evaluates a novel S1P transport blocker, SLF80821178, showing efficacy in multiple sclerosis without the cardiac side effects of SRMs, but with less lymphopenia and unchanged lymph S1P levels.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

An optimized somatic embryo transformation system assisted homozygous edited rubber tree generation method mediated by CRISPR/Cas9

This study develops a CRISPR/Cas9-based method to generate homozygous edited rubber tree plants by optimizing somatic embryo transformation and subculture procedures.

High immigration rates critical for establishing emigration-driven diversity in microbial communities

The paper investigates how microbial dispersal affects community diversity under competition, finding that high immigration rates enhance diversity through emigration.

The trade-off between individual metabolic specialization and versatility determines the metabolic efficiency of microbial communities

This study shows that microbial communities with metabolic redundancy outperform both specialized and division-of-labor systems in naphthalene degradation.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

Novel TRPM7 inhibitors with potent anti-inflammatory effects in vivo

This study identifies novel TRPM7 inhibitors with potent in vivo anti-inflammatory effects, showing efficacy in a mouse model of endotoxemia.

Tomato CYP94C1 terminates jasmonate signaling during fruit ripening by inactivating bioactive jasmonoyl-L-isoleucine

This study identifies CYP94C1 as a key enzyme in tomato that terminates jasmonate signaling during ripening by converting bioactive JA-Ile to an inactive form, thereby reducing susceptibility to necrotrophic pathogens.

Modification of social cheating facilitates the stabilization and chronic infection of polymorphic Pseudomonas aeruginosa population

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

This study investigates the effects of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes using mouse models, revealing allele-specific and tissue-specific molecular requirements for cilia motor assembly.

Enhancing Mitochondrial Functions by Optogenetic Clustering

This paper develops an optogenetic method to control mitochondrial clustering and shows it enhances mitochondrial functions.

CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae.

This study reveals polyphyletic origins of clerodane diterpene biosynthesis in Lamiaceae by analyzing genomes and metabolic pathways of three species.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

Gut feelings: Associations of emotions and emotion regulation with the gut microbiome in women

This study investigates associations between emotions, emotion regulation, and the gut microbiome in women, finding links between emotional states and microbial diversity and pathways.

Identification of Microbial Flora and Isolation of Functional Strains Related to the Degradation of Domestic Waste

The paper identifies microbial flora in food waste compost and isolates functional strains with potential for improving waste treatment efficiency.

Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

The paper uses super-resolution microscopy and a fluorescent probe to analyze lysosome spatial organization relative to mitochondria, revealing changes in distance distribution patterns during autophagy and linking lysosome positioning to mitochondrial health.

Lactate Increases Stemness of CD8+ T Cells to Augment Anti-Tumor Immunity

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

Characterization of pyridomycin B reveals the formation of functional groups in antimycobacterial pyridomycin

This study characterizes pyridomycin B, a pyridomycin analogue, revealing that Pyr2 catalyzes ketoreduction and double bond formation in a unique energy-saving manner, contributing to the formation of functional groups in pyridomycin.

Even allocation of benefits stabilizes microbial community engaged in metabolic division of labor

The paper develops a theoretical framework and validates it experimentally to show that even allocation of benefits stabilizes microbial communities engaged in metabolic division of labor.

Evidence for the Presence of Hyphae and Fruiting Body Calcium Oxalate Crystallites in Schizophyllum commune

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

Predictors of zoonotic potential in helminths

The paper identifies predictors of zoonotic potential in helminths using a global dataset, finding that transmission and geographic traits are more important than morphology or epidemiology.

Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells

This paper develops a non-viral method for efficient T cell genome editing using modified plasmids, achieving CAR-T cell functionality comparable to AAV-based methods.

Partial spontaneous intersubunit rotations in actively translating ribosomes

This study uses high-speed single-molecule TIRF microscopy to show that actively translating ribosomes undergo partial spontaneous rotations between three states, bridging conflicting models of ribosome dynamics.

The translational landscape of SARS-CoV-2 and infected cells

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.