P. Johri

Developing an evolutionary baseline model for humans: jointly inferring purifying selection with population history

The paper develops a baseline model for the Yoruba population to jointly infer purifying selection and population history, finding recent population growth and a distribution of fitness effects skewed towards neutral mutations.

Recommendations for improving statistical inference in population genomics

The paper discusses challenges in population genomics due to data abundance and highlights best practices for statistical inference and model fitting.

Revisiting the notion of deleterious sweeps

The paper examines how fixation of mildly deleterious mutations affects polymorphism patterns and divergence between populations, finding minor but measurable impacts on private variants and FST.

The impact of purifying and background selection on the inference of population history: problems and prospects

This paper examines how purifying and background selection affect population history inference, showing biases in demographic estimates and proposing a correction method using the distribution of fitness effects.

Towards an evolutionarily appropriate null model: jointly inferring demography and purifying selection

The paper develops a statistical framework to jointly infer demography and purifying selection, finding slower population growth in Drosophila melanogaster when purifying selection is considered.

Universal trends of post-duplication evolution revealed by the genomes of 13 Paramecium species sharing an ancestral whole-genome duplication.

This study analyzes 13 Paramecium species with a shared ancestral whole-genome duplication to reveal trends in post-duplication gene retention and selective pressures.

Population genetics of Paramecium mitochondrial genomes: recombination, mutation spectrum, and efficacy of selection.

This study analyzes mitochondrial genome variation in Paramecium species, finding high conservation of gene order, variable tRNA content, increased GC content in the P. aurelia complex, and no evidence of recombination.