L. Excoffier

Recommendations for improving statistical inference in population genomics

The paper discusses challenges in population genomics due to data abundance and highlights best practices for statistical inference and model fitting.

Strong neutral sweeps occurring during a population contraction

The paper analyzes how population contractions can create diversity valleys similar to selective sweeps, showing neutral processes can mimic selection signals.

Demogenomic modeling of the timing and the processesof early European farmers differentiation

This study uses demogenomic modeling to show early European farmers arose from post-LGM mixing of Near Eastern and Western hunter-gatherer populations and experienced extreme genetic drift during westward expansion.

The impact of purifying and background selection on the inference of population history: problems and prospects

This paper examines how purifying and background selection affect population history inference, showing biases in demographic estimates and proposing a correction method using the distribution of fitness effects.

Runs of homozygosity in killer whale genomes provide a global record of demographic histories

This study uses genome-wide runs of homozygosity in killer whale genomes to infer demographic histories and patterns of inbreeding across different populations.

Transition from background selection to associative overdominance promotes diversity in regions of low recombination

The paper models how multi-locus dynamics can shift genetic diversity from background selection to associative overdominance in low recombination regions, identifying 21 human genomic regions where this occurs.

Polygenic patterns of adaptive introgression in modern humans are mainly shaped by response to pathogens

The paper identifies polygenic adaptive introgression in modern humans, showing it is mainly driven by independent selection episodes, with some epistatic signals in immunity and metabolism.

Mutation load dynamics during environmentally-driven range shifts

This study compares the effects of range expansion and range shift on genetic diversity and fitness loss in species, finding that shift speed significantly impacts fitness evolution and recovery.

The evolutionary history of Nebraska deer mice: local adaptation in the face of strong gene flow

This study examines the demographic and selective history of deer mice in Nebraska, finding that gene flow homogenizes most of the genome but the Agouti locus shows local adaptation due to cryptic coloration.

Detection of pathways affected by positive selection in primate lineages ancestral to humans

The paper detects pathways affected by positive selection in primate lineages ancestral to humans, identifying significant signals in immune response, sensory perception, metabolism, and energy production.

Accumulation of deleterious mutations during bacterial range expansions

This study shows that mutator bacteria accumulate deleterious mutations during range expansion, reducing their fitness, while low mutation rate strains maintain stability.