S. P. Pfeifer

Developing an evolutionary baseline model for humans: jointly inferring purifying selection with population history

The paper develops a baseline model for the Yoruba population to jointly infer purifying selection and population history, finding recent population growth and a distribution of fitness effects skewed towards neutral mutations.

Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

This study shows that pre-existing CMV immunity in nonhuman primates reduces placental transmission and fetal loss during reinfection compared to primary infection.

Recommendations for improving statistical inference in population genomics

The paper discusses challenges in population genomics due to data abundance and highlights best practices for statistical inference and model fitting.

Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates

The paper evaluates variation in germline mutation rate estimates across labs using a standardized pedigree of rhesus macaques, highlighting methodological differences and the need for standardization.

The demographic history of African Drosophila melanogaster

This paper quantitatively models the demographic history of African Drosophila melanogaster populations, including ancestral Zambian and colonized West African populations.

The evolutionary history of Nebraska deer mice: local adaptation in the face of strong gene flow

This study examines the demographic and selective history of deer mice in Nebraska, finding that gene flow homogenizes most of the genome but the Agouti locus shows local adaptation due to cryptic coloration.

The demographic and adaptive history of the African green monkey

This study analyzes the demographic and adaptive history of African green monkeys using genetic data from five populations, finding population fragmentation and identifying candidate regions for pathogen adaptation.