Author

G. McVean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 4 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. Kelleher· 2 shared A. E. Neumann· 1 shared A. Eyre-Walker· 1 shared A. Ragsdale· 1 shared A. Regev· 1 shared A. Subramanian· 1 shared A. W. Wohns· 1 shared B. A. Payseur· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersEvolutionary Biology

J. Kelleher

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Author profile →

5 papers

Recent·Most cited

Recommendations for improving statistical inference in population genomics

P. Johri, C. F. Aquadro, M. Beaumont, B. Charlesworth, L. Excoffier, A. Eyre-Walker, P. D. Keightley, M. Lynch, G. McVean, B. A. Payseur, S. P. Pfeifer, W. Stephan, J. D. Jensen

The paper discusses challenges in population genomics due to data abundance and highlights best practices for statistical inference and model fitting.

bioRxiv · Oct 27, 2021Evolutionary Biology

Parental-fetal interplay of immune genes leads to intrauterine growth restriction

G. Kaur, C. B. M. Porter, O. Ashenberg, J. Lee, S. J. Riesenfeld, M. Hofree, M. Aggelakopoulou, A. Subramanian, S. B. Kuttikkatte, K. E. Attfield, C. A. E. Desel, J. L. Davies, H. G. Evans, I. Avraham-Davidi, L. T. Nguyen, , L. Fugger

This study identifies a maternal-fetal immune interaction involving KIR2DL1 and HLA-C*05 that causes intrauterine growth restriction in a humanised mouse model.

bioRxiv · Mar 26, 2021Immunology

Coupling Wright-Fisher and coalescent dynamics for realistic simulation of population-scale datasets

D. Nelson, J. Kelleher, A. Ragsdale, G. McVean, S. Gravel

This paper extends the coalescent simulator msprime with a Wright-Fisher model to better simulate population-scale datasets, improving accuracy for long genomic regions and large samples.

bioRxiv · Jun 18, 2019Evolutionary Biology

Inferring the ancestry of everyone

J. Kelleher, Y. Wong, P. Albers, A. W. Wohns, G. McVean

The paper introduces an efficient algorithm for inferring whole-genome genealogies from large datasets, demonstrating its accuracy and scalability on human genetic data.

bioRxiv · Nov 1, 2018Evolutionary Biology

LOW-BIAS RNA SEQUENCING OF THE HIV-2 GENOME FROM BLOOD PLASMA

K. L. James, T. de Silva, K. Brown, H. Whittle, S. Taylor, G. McVean, J. Esbjörnsson, S. Rowland-Jones

This study uses RNA-Seq without PCR amplification to sequence the HIV-2 genome from plasma samples, revealing low genetic diversity in the vpx gene.

bioRxiv · May 10, 2018Microbiology