B. Charlesworth

Do deleterious mutations promote the evolution ofrecombination suppression between X and Y chromosomes?

The paper evaluates a model for recombination suppression between X and Y chromosomes, finding that the proposed selective advantage of Y-linked inversions is likely overstated due to biased simulation methods.

The effects of weak selection on neutral diversity at linked sites

The paper examines how weak selection at linked sites affects neutral diversity, showing that it can increase diversity under certain conditions.

Recommendations for improving statistical inference in population genomics

The paper discusses challenges in population genomics due to data abundance and highlights best practices for statistical inference and model fitting.

Selective sweeps influence diversity over large regions of the mouse genome

This study estimates the effects of positive selection on protein-coding and regulatory mutations in wild mice, finding stronger fitness impacts from coding mutations but higher frequency in regulatory regions.

Revisiting the notion of deleterious sweeps

The paper examines how fixation of mildly deleterious mutations affects polymorphism patterns and divergence between populations, finding minor but measurable impacts on private variants and FST.

Studying models of balancing selection usingphase-type theory

The paper uses phase-type theory to analyze how balancing selection affects polymorphism patterns in linked neutral regions across different models of BLS.

How good are predictions of the effects of selective sweeps on levels of neutral diversity?

The paper evaluates the accuracy of predictions for how selective sweeps affect neutral diversity, showing that a simple approximation can be substantially inaccurate when recombination rates are moderate relative to selection coefficients.

The impact of purifying and background selection on the inference of population history: problems and prospects

This paper examines how purifying and background selection affect population history inference, showing biases in demographic estimates and proposing a correction method using the distribution of fitness effects.

Towards an evolutionarily appropriate null model: jointly inferring demography and purifying selection

The paper develops a statistical framework to jointly infer demography and purifying selection, finding slower population growth in Drosophila melanogaster when purifying selection is considered.

Patterns of genetic variability in genomic regions with low rates of recombination

The paper investigates genetic variability patterns in low recombination regions, proposing associative overdominance explains reduced skew observed in simulations and population genomic studies.

The determinants of genetic diversity in butterflies - Lewontin's paradox revisited

This study examines genetic diversity in European butterflies and finds it correlates with body size and genetic map length, not population size or fecundity.

The effects on neutral variability of recurrent selective sweeps and background selection

The paper derives new theoretical expressions for neutral variability under recurrent selective sweeps and background selection, validated by simulations in Drosophila.

Mutational load, inbreeding depression and heterosis in subdivided populations

The paper assesses how mutation rates and selection coefficients explain inbreeding depression, heterosis, and genetic load in subdivided populations using population genetics models.