MicroRNA-221/222-expression in HSC and MPP safeguards their quiescence and multipotency by downregulating stress-independent and dependent expression of IEG and of several myelo/granulopoiesis-enhancing target genes.
P. K. Jani, G. Petkau, Y. Kawano, U. Klemm, G. M. Guerra, G. A. Heinz, F. Heinrich, P. Durek, M.-F. Mashreghi, F. Melchers
This study shows that miR-221/222 in HSC and MPP maintains quiescence and multipotency by suppressing IEGs and myelo/granulopoiesis genes, with implications for improving bone marrow transplants.
bioRxiv · Jan 30, 2023 · PreprintImmunology