P. Kalita-de Croft

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

The paper characterizes immune cell subsets in brain metastases and finds that low TILs correlate with high VISTA expression and high TILs with activated microglia.

This study investigates the HER4/YAP axis in breast cancer brain metastasis using patient samples, finding HER4 phosphorylation is specific to BrM but YAP phosphorylation is not a major consequence of HER4 activation.

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.