Author

S. R. Lakhani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. M. Saunus· 5 shared J. R. Kutasovic· 3 shared M. Lim· 3 shared P. Kalita-de Croft· 3 shared P. T. Simpson· 3 shared X. M. De Luca· 3 shared A. E. McCart Reed· 2 shared B. W. Day· 2 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersCancer Biology

J. M. Saunus

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6 papers

Recent·Most cited

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease.

L. K. Shewell, C. J. Day, J. R. Kutasovic, J. L. Abrahams, J. Wang, J. Poole, C. Niland, K. Ferguson, J. M. Saunus, S. R. Lakhani, M. v. Itzstein, J. C. Paton, A. W. Paton, M. P. Jennings

This study measures Neu5Gc serum biomarker levels in breast cancer patients and finds elevated levels at all disease stages, with high sensitivity and specificity for detection.

bioRxiv · Jun 21, 2021Cancer Biology

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

J. M. Saunus, X. M. De Luca, K. Northwood, A. Raghavendra, A. Hasson, A. E. McCart Reed, M. Lim, S. Lal, A. C. Vargas, J. R. Kutasovic, A. J. Dalley, M. Miranda, E. Kalaw, P. Kalita-de Croft, I. Gresshoff, , S. R. Lakhani

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

bioRxiv · Mar 30, 2021 · PreprintCancer Biology

A short ERK5 isoform modulates nucleocytoplasmic shuttling of active ERK5 and associates with poor survival in breast cancer

M. S. Miranda, J. M. Saunus, S. Akgül, M. Moradi Marjaneh, J. R. Kutasovic, W. Shi, O. Chatterjee, F. Casciello, E. Rozali, H. Y. Handoko, A. P. Wiegmans, T. Liu, J. S. Lee, B. W. Day, S. Edwards, , F. Al-Ejeh

This paper identifies a short ERK5 isoform that promotes extranuclear localization of active ERK5, driving EMT and poor survival in breast cancer.

bioRxiv · Mar 23, 2021Cancer Biology

Characterisation of immune cell subsets of tumour infiltrating lymphocytes in brain metastases

P. Kalita-de Croft, H. Chittoory, T. Nguyen, J. M. Saunus, W. Gyeong Kim, A. McCart Reed, M. Lim, X. M. De Luca, K. Ferguson, C. Niland, R. Mazzieri, R. Dolcetti, P. T. Simpson, S. R. Lakhani

The paper characterizes immune cell subsets in brain metastases and finds that low TILs correlate with high VISTA expression and high TILs with activated microglia.

bioRxiv · Feb 10, 2021Pathology

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

W. S. Teo, H. Holliday, N. Karthikeyan, A. S. Cazet, D. L. Roden, K. Harvey, C. V. Konrad, R. Murali, B. A. Varghese, A. P. T., C.-L. Chan, A. McFarland, S. Junankar, S. Ye, J. Yang, , R. Nair

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

bioRxiv · Mar 11, 2020 · PreprintCancer Biology

Immunophenotyping of HER4/YAP axis in breast cancer brain metastasis

P. Kalita-de Croft, M. Lim, X. M. de Luca, B. W. Day, J. M. Saunus, S. R. Lakhani

This study investigates the HER4/YAP axis in breast cancer brain metastasis using patient samples, finding HER4 phosphorylation is specific to BrM but YAP phosphorylation is not a major consequence of HER4 activation.

bioRxiv · Jan 29, 2020 · PreprintPathology