K. K. Khanna

Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

This paper shows copper chelation inhibits TGF-β pathways and reduces EMT in cancer cells, potentially offering a new therapeutic strategy for targeting TGF-β in cancer.

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

This study shows that overexpression of B-Crystallin in mice promotes tumorigenesis and metastasis by enhancing cell survival and inhibiting apoptosis.

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

This study shows that Cep55 regulates PI3K/Akt signaling, essential for neocortical development and ciliogenesis, using mouse models and human organoids.

Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

Cep55 overexpression promotes genomic instability and tumorigenesis in mice

This study shows that Cep55 overexpression causes genomic instability and tumorigenesis in mice by promoting mitotic errors and disrupting DNA repair mechanisms.

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.