Author

J. M. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. E. Sealover· 3 shared R. L. Kortum· 3 shared B. R. Daley· 2 shared A. Frank· 1 shared A. J. Linke· 1 shared A. Linke· 1 shared B. Daley· 1 shared B. Mair· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

N. E. Sealover

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

B. R. Daley, N. E. Sealover, E. Sheffels, J. M. Hughes, D. Gerlach, M. H. Hofmann, K. Kostyrko, B. Mair, A. Linke, Z. Beckley, A. Frank, C. L. Dalgard, R. L. Kortum

This study shows that SOS1 inhibition with BI-3406 enhances G12C inhibitor efficacy and delays resistance in lung adenocarcinoma by targeting resistance mechanisms and drug-tolerant persister cells.

bioRxiv · Dec 7, 2023 · PreprintCancer Biology

Unravelling the mystery of endemic versus translocated populations of the endangered Australian lungfish (Neoceratodus forsteri)

R. Biello, S. Ghirotto, D. J. Schmidt, S. Fuselli, D. T. Roberts, T. Espinoza, J. M. Hughes, G. Bertorelle

This study uses genetic markers and Approximate Bayesian Computation to determine if Australian lungfish populations are endemic or translocated, finding evidence of an endemic gene pool in specific rivers.

bioRxiv · Mar 24, 2023Evolutionary Biology

In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies

N. E. Sealover, P. L. Theard, J. M. Hughes, A. J. Linke, B. R. Daley, R. L. Kortum

This paper introduces an in situ resistance assay to model acquired resistance to RTK/RAS pathway targeted therapies and shows SHP2 inhibitors can delay resistance development.

bioRxiv · Jan 27, 2023Cancer Biology

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

B. Daley, H. M. Vieira, C. Rao, J. M. Hughes, Z. M. Beckley, D. H. Huisman, D. Chatterjee, N. E. Sealover, K. Cox, J. W. Askew, R. A. Svoboda, K. W. Fisher, R. E. Lewis, R. L. Kortum

This study shows that targeting SOS1 or KSR1 enhances MEK inhibitor efficacy and prevents resistance in KRAS-mutated cancers, depending on specific KRAS and co-mutation status.

bioRxiv · Dec 6, 2022Cancer Biology