Author

P. Madeddu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. Avolio· 3 shared M. Caputo· 2 shared M. Carrabba· 2 shared M. Gamez· 2 shared A. C. Thomas· 1 shared A. Caporali· 1 shared A. D. Davidson· 1 shared A. Faulkner· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

E. Avolio

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of MMP 2 protects the endothelial glycocalyx and improves diastolic function in diabetic cardiomyopathy

S. Buffonge, Y. Qiu, S. Fawaz, M. Gamez, M. Crompton, M. J. Butler, G. I. Welsh, P. Madeddu, R. R. Foster, S. C. Satchell

This study shows that inhibiting MMP2/9 protects the endothelial glycocalyx and improves diastolic function in diabetic cardiomyopathy.

bioRxiv · Dec 18, 2023 · PreprintPhysiology

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

E. Avolio, M. Carrabba, R. Milligan, M. Kavanagh Williamson, A. P. Beltrami, K. Gupta, K. T. Elvers, M. Gamez, R. Foster, K. Gillespie, F. Hamilton, D. Arnold, I. Berger, M. Caputo, A. D. Davidson, , P. Madeddu

This paper shows that SARS-CoV-2 Spike protein causes cardiac pericyte dysfunction through CD147-mediated signaling, without infecting the cells.

bioRxiv · Dec 21, 2020Cell Biology

Contractile reprogramming of cardiac pericytes by MEK inhibition promotes arteriologenesis of the ischemic heart

E. Avolio, R. Katare, A. C. Thomas, A. Caporali, D. Schwenke, M. Meloni, M. Caputo, P. Madeddu

This study shows that MEK inhibition reprograms cardiac pericytes into contractile cells, promoting arteriologenesis in ischemic hearts.

bioRxiv · Nov 10, 2020 · PreprintCell Biology

Human saphenous vein provides a unique source of anti-calcific pericytes for prosthetic cardiac valve engineering

E. Jover, M. Fagnano, W. Cathery, S. Slater, E. Pisanu, Y. Gu, E. Avolio, D. Bruno, D. Baz-Lopez, A. Faulkner, M. Carrabba, P. Madeddu

This study identifies human adventitial pericytes from saphenous vein as anti-calcific cells for prosthetic cardiac valve engineering, showing resistance to osteochondrogenic induction via miR-132 regulation.

bioRxiv · Jul 14, 2020 · PreprintCell Biology

A Critical Role for Perivascular Cells in Amplifying Viral Haemorrhage Induced by Dengue Virus Non-Structural Protein 1

Y. P. Cheung, V. Mastrullo, D. Maselli, T. Butsabong, P. Madeddu, K. Maringer, P. Campagnolo

This study shows that pericytes amplify NS1-induced vascular leakage in dengue by contact-independent paracrine signaling, highlighting their role in severe dengue pathogenesis.

bioRxiv · Feb 13, 2020Microbiology