Author

P. Manfredi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

U. Jenal· 3 shared I. Santi· 2 shared A. Egli· 1 shared A. Harms· 1 shared A. Kaczmarczyk· 1 shared A. Klotz· 1 shared A. Reinders· 1 shared B. Sellner· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

U. Jenal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Toxin-mediated depletion of nicotinamide dinucleotides drives persister formation in a human pathogen

I. Santi, R. Dias Teixeira, P. Manfredi, D. Spiess, G. Mas, A. Klotz, N. Zamboni, S. Hiller, U. Jenal

This study shows that the RES domain TA system in P. aeruginosa promotes persister formation by depleting NAD and NADP under nutrient stress, enhancing bacterial survival during antibiotic treatment.

bioRxiv · Sep 28, 2023 · PreprintMicrobiology

Digital control of c-di-GMP in E. coli balances population-wide developmental transitions and phage sensitivity

A. Reinders, B. Sellner, F. Fadel, M. van Berkum, A. Kaczmarczyk, S. Ozaki, J. Rueher, P. Manfredi, M. Sangermani, A. Harms, C. Perez, T. Schirmer, U. Jenal

This study shows E. coli uses a digital switch to convert c-di-GMP dynamics into binary states, enabling population-level developmental transitions and phage resistance.

bioRxiv · Oct 1, 2021 · PreprintMicrobiology

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections

I. Santi, P. Manfredi, E. Maffei, A. Egli, U. Jenal

This study shows that antibiotic tolerance evolves before resistance in Pseudomonas aeruginosa, promoting resistance development in chronic infections.

bioRxiv · Oct 23, 2020Microbiology