Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells
D. Huhn, P. Marti-Rodrigo, S. Mouron, C. Hansel, K. Tschapalda, B. Porebski, M. Haggblad, L. Lidemalm, M. A. Quintela-Fandino, J. Carreras-Puigvert, O. Fernandez-Capetillo
This study shows that estrogen deprivation in ER-positive breast cancer cells increases PD-L1 expression and triggers an immunosuppressive program, leading to resistance against T-cell killing.
bioRxiv · Aug 28, 2019 · PreprintCancer Biology