J. Carreras-Puigvert

From Pixels to Phenotypes: Integrating Image-Based Profiling with Cell Health Data Improves Interpretability

This study introduces BioMorph space, which integrates Cell Painting and Cell Health data to improve the interpretability of morphological features and reveal compound mechanisms of action.

Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

The paper uses Cell Painting to assess combination effects of BPA, CTAB, and DBTDL on human cell lines, showing dose- and combination-dependent morphological changes.

An Open-Source Modular Framework for Automated Pipetting and Imaging Applications

This paper presents an open-source framework for automated pipetting and imaging using affordable tools, enabling reproducible and customizable lab experiments.

A phenomics approach for in vitro antiviral drug discovery

This paper introduces a phenomics approach combining Cell Painting and antibody-based detection to screen antiviral drugs in infected cells, showing effective compounds reverse morphological changes.

Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells

This study shows that estrogen deprivation in ER-positive breast cancer cells increases PD-L1 expression and triggers an immunosuppressive program, leading to resistance against T-cell killing.