Author

P. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 3 Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Research Focus:ecology & biodiversity· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Bowman· 3 shared H. F. Klein· 2 shared R. Pither· 2 shared A. aimon· 1 shared A. Brennan· 1 shared A. Carberry· 1 shared A. Clark· 1 shared A. Dias· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersEcology

J. Bowman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Using sentinel nodes to evaluate changing connectivity in a protected areas network

P. O'Brien, N. Carr, J. Bowman

The paper evaluates connectivity in protected areas networks using sentinel nodes and circuit theory to detect changes from simulated land-use changes.

bioRxiv · Apr 25, 2023Ecology

Integrating carbon stocks and wildlife connectivity for nature-based climate solutions

P. O'Brien, J. S. Gunn, A. Clark, J. Gleeson, R. Pither, J. Bowman

The paper identifies areas in Ontario that maximize carbon storage and terrestrial connectivity, finding weak positive correlation and highlighting gaps in protected areas coverage.

bioRxiv · Aug 22, 2022Ecology

Areas Important for Ecological Connectivity Throughout Canada

R. Pither, P. O'Brien, A. Brennan, K. Hirsh-Pearson, J. Bowman

This study uses circuit theory to analyze ecological connectivity across Canada, revealing patterns influenced by geography and human development, and validating results with wildlife data.

bioRxiv · Dec 14, 2021 · PreprintEcology

Design and proof-of-concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain

D. I. Staquicini, F. H. F. Tang, C. Markosian, V. J. Yao, F. I. Staquicini, E. Dodero Rojas, V. G. Contessoto, D. Davis, P. O'Brien, N. Habib, T. L. Smith, N. Bruiners, R. L. Sidman, M. L. Gennaro, E. C. Lattime, , R. Pasqualini

This paper designs and evaluates phage-based and AAVP-based vaccination strategies for SARS-CoV-2 that induce systemic antibody responses in mice, with potential for a cold-free supply chain.

bioRxiv · Mar 15, 2021Microbiology

Multiplexed experimental strategies for fragment library screening using SPR biosensors

E. A. FitzGerald, D. Vagrys, G. Opassi, H. F. Klein, D. J. Hamilton, P. Boronat, D. Cederfelt, V. O. Talibov, M. Abramsson, A. Moberg, M. T. Lindgren, C. Holmgren, D. Dobritzsch, B. Davis, P. O'Brien, , U. H. Danielson

The paper presents multiplexed SPR biosensor strategies for fragment library screening, improving hit identification for challenging targets.

bioRxiv · Dec 23, 2020 · PreprintBiophysics

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

A. Douangamath, D. Fearon, P. Gehrtz, T. Krojer, P. Lukacik, C. D. Owen, E. Resnick, C. Strain-Damerell, A. aimon, P. Abranyi-Balogh, J. Brandao-Neto, A. Carberry, G. Davison, A. Dias, T. D. Downes, , M. A. Walsh

The paper identifies fragment hits against SARS-CoV-2 main protease using crystallography and mass spectrometry, revealing structural insights for drug design.

bioRxiv · May 27, 2020Biophysics