Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer
L. Pedersen, P. Panahandeh, M. I. Siraji, S. Knappskog, P. E. Lonning, Q. Zhu, R. Gordillo, P. E. Scherer, A. Molven, K. Teigen, N. Halberg
This study identifies PAQR4 as a Golgi-localized ceramidase upregulated in breast cancer, whose depletion induces apoptosis by accumulating ceramides.
bioRxiv · Sep 18, 2019Cancer Biology