Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease
Z. Wang, S. Zhu, Y. Jia, Y. Wang, N. Kubota, N. Fujiwara, R. Gordillo, C. Lewis, M. Zhu, T. Sharma, L. Li, Q. Zeng, Y.-H. Lin, M.-H. Hsieh, P. Gopal, , H. Zhu
The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.
bioRxiv · Mar 20, 2023Cell Biology