Author

P. E. Scherer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Q. Zhu· 2 shared R. Gordillo· 2 shared Z. Zhang· 2 shared A. Bouloumie· 1 shared A. Molven· 1 shared A. Toulet· 1 shared B. Levine· 1 shared B. Malavaud· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Q. Zhu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Extra-cellular matrix remodeling as a unique mechanism of expansion of periprostatic adipose tissue: a potential driver of prostate cancer aggressiveness

D. Esteve, A. Toulet, M. Roumiguie, D. Bu, M. Lacombe, S. Pericart, C. Belles, C. Manceau, C. Houel, M. Ducoux-Petit, N. Van Acker, S. Dauvillier, Y. Jia, M. Hernandez, M. Moutahir, , C. Muller

The paper defines abundant periprostatic adipose tissue using a statistical approach and shows it is associated with prostate cancer aggressiveness through extracellular matrix remodeling.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

Quantitative Phosphoproteomic Analyses Identify STK11IP as a Lysosome-Specific Substrate of mTORC1 that Regulates Lysosomal Acidification

Z. Zi, Z. Zhang, Q. Feng, C. Kim, P. E. Scherer, J. Gao, B. Levine, Y. Yu

This study identifies STK11IP as a lysosome-specific mTORC1 substrate that regulates lysosomal acidification and autophagy, with implications for therapeutic targeting of autophagy-related diseases.

bioRxiv · Aug 18, 2021Cell Biology

Adiponectin Preserves Metabolic Fitness During Aging

P. E. Scherer, N. Li, Z. Zhang, S. Zhao, Y. Zhu, C. M. Gliniak, L. Vishvanath, Y. A. An, M.-y. Wang, Y. Deng, Q. Zhu, T. Onodera, O. Oz, R. Gordillo, R. K. Gupta, , V. D. Dixit

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

bioRxiv · Jan 14, 2021 · PreprintCell Biology

Fat Tissue Regulates the Pathogenesis and Severity of Cardiomyopathy in Murine Chagas Disease

J. F. Nagajyothi, K. Lizardo, J. P. Ayyappan, N. Oswal, L. M. Weiss, P. E. Scherer

This study shows that fat tissue loss in mice infected with Trypanosoma cruzi worsens cardiac parasite load, inflammation, and severity of chronic Chagas cardiomyopathy.

bioRxiv · Nov 25, 2020Pathology

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer

L. Pedersen, P. Panahandeh, M. I. Siraji, S. Knappskog, P. E. Lonning, Q. Zhu, R. Gordillo, P. E. Scherer, A. Molven, K. Teigen, N. Halberg

This study identifies PAQR4 as a Golgi-localized ceramidase upregulated in breast cancer, whose depletion induces apoptosis by accumulating ceramides.

bioRxiv · Sep 18, 2019Cancer Biology