Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics
I. L. Rempel, M. M. Crane, A. Mishra, D. P. Jansen, G. Janssens, P. Popken, M. Kaeberlein, E. van der Giessen, P. Onck, A. Steen, L. M. Veenhoff
This study shows that ageing mitotic cells experience reduced NPC component abundance and misassembled NPCs, leading to decreased nuclear transport and increased compartmentalization.
bioRxiv · Nov 24, 2018Cell Biology