Author

P. Onck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

E. Van der Giessen· 5 shared A. Fragasso· 2 shared C. Dekker· 2 shared H. Jafarinia· 2 shared M. Dekker· 2 shared A. Barth· 1 shared A. Mishra· 1 shared A. Steen· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersBiophysics

E. Van der Giessen

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Author profile →

6 papers

Recent·Most cited

C9orf72 polyPR directly binds to various nuclear transport components

H. Jafarinia, E. Van der Giessen, P. Onck

This study investigates how polyPR, a toxic DPR from C9orf72, directly interacts with nuclear transport components, revealing potential mechanisms of NCT disruption in C9orf72-ALS.

bioRxiv · Jun 22, 2023Biophysics

Diameter Dependence of Transport through Nuclear Pore Complex Mimics Studied Using Optical Nanopores

N. Klughammer, A. Barth, M. Dekker, A. Fragasso, P. Onck, C. Dekker

The paper studies transport selectivity through NPC mimics by measuring translocation rates of Kap95 and BSA across varying pore sizes and observes a decrease in selectivity for larger pores.

bioRxiv · Feb 18, 2023Biophysics

Liquid-liquid phase separation of intrinsically disordered FG-Nups is driven by highly-dynamic hydrophobic FG-motifs

M. Dekker, E. van der Giessen, P. Onck

This study investigates the liquid-liquid phase separation of FG-Nups in yeast NPCs, identifying hydrophobic FG-motifs as key drivers and categorizing FG-Nups into two functional classes based on their phase separation behavior.

bioRxiv · Sep 20, 2022Biophysics

Transport receptor occupancy in Nuclear Pore Complex mimics

A. Fragasso, H. W. de Vries, J. Andersson, E. O. van der Sluis, E. van der Giessen, P. Onck, C. Dekker

This study investigates Kap95 binding in Nsp1-coated nanopores, showing two Kap populations and limited Kap occupancy due to steric constraints.

bioRxiv · Dec 22, 2021Biophysics

Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS/FTD

H. Jafarinia, E. van der Giessen, P. Onck

This study uses a molecular dynamics model to show that DPR length and concentration affect phase separation, with critical lengths matching toxicity thresholds in ALS/FTD.

Biophysical Journal · Aug 1, 2020Peer-reviewedBiophysics

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

I. L. Rempel, M. M. Crane, A. Mishra, D. P. Jansen, G. Janssens, P. Popken, M. Kaeberlein, E. van der Giessen, P. Onck, A. Steen, L. M. Veenhoff

This study shows that ageing mitotic cells experience reduced NPC component abundance and misassembled NPCs, leading to decreased nuclear transport and increased compartmentalization.

bioRxiv · Nov 24, 2018Cell Biology