Author

E. van der Giessen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Organism:yeast· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

P. Onck· 5 shared H. Jafarinia· 3 shared A. Fragasso· 2 shared C. Dekker· 2 shared E. O. van der Sluis· 2 shared H. W. de Vries· 2 shared P. R. Onck· 2 shared A. Mishra· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBiophysics

P. Onck

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

C9orf72 polyPR directly binds to various nuclear transport components

H. Jafarinia, E. Van der Giessen, P. Onck

This study investigates how polyPR, a toxic DPR from C9orf72, directly interacts with nuclear transport components, revealing potential mechanisms of NCT disruption in C9orf72-ALS.

bioRxiv · Jun 22, 2023Biophysics

Liquid-liquid phase separation of intrinsically disordered FG-Nups is driven by highly-dynamic hydrophobic FG-motifs

M. Dekker, E. van der Giessen, P. Onck

This study investigates the liquid-liquid phase separation of FG-Nups in yeast NPCs, identifying hydrophobic FG-motifs as key drivers and categorizing FG-Nups into two functional classes based on their phase separation behavior.

bioRxiv · Sep 20, 2022Biophysics

Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors

H. Jafarinia, E. Van der Giessen, P. R. Onck

This study uses molecular dynamics simulations to show how poly-PR from C9orf72 repeat expansions interacts with Kap{beta} proteins, affecting nucleocytoplasmic transport.

bioRxiv · May 5, 2022Biophysics

Transport receptor occupancy in Nuclear Pore Complex mimics

A. Fragasso, H. W. de Vries, J. Andersson, E. O. van der Sluis, E. van der Giessen, P. Onck, C. Dekker

This study investigates Kap95 binding in Nsp1-coated nanopores, showing two Kap populations and limited Kap occupancy due to steric constraints.

bioRxiv · Dec 22, 2021Biophysics

Clearing-induced tissue shrinkage: Novel observation of a thickness size effect.

R. C. M. Vulders, R. C. van Hoogenhuizen, E. van der Giessen, P. J. van der Zaag

The paper reports that shrinkage from a clearing agent decreases with increasing sample size and provides an analytical description of this effect.

PLOS ONE · Dec 16, 2021Peer-reviewedBiophysics

A designer FG-Nup that reconstitutes the selective transport barrier of the Nuclear Pore Complex

A. Fragasso, H. W. de Vries, E. O. van der Sluis, E. van der Giessen, P. R. Onck, C. Dekker

This study designs an artificial FG-Nup that mimics natural Nups and demonstrates selective transport behavior similar to native NPCs.

Nature Communications · Mar 31, 2021Peer-reviewedBiophysics

Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS/FTD

H. Jafarinia, E. van der Giessen, P. Onck

This study uses a molecular dynamics model to show that DPR length and concentration affect phase separation, with critical lengths matching toxicity thresholds in ALS/FTD.

Biophysical Journal · Aug 1, 2020Peer-reviewedBiophysics

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

I. L. Rempel, M. M. Crane, A. Mishra, D. P. Jansen, G. Janssens, P. Popken, M. Kaeberlein, E. van der Giessen, P. Onck, A. Steen, L. M. Veenhoff

This study shows that ageing mitotic cells experience reduced NPC component abundance and misassembled NPCs, leading to decreased nuclear transport and increased compartmentalization.

bioRxiv · Nov 24, 2018Cell Biology