Author

P. R. Onck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Approach:biophysical modeling· 2 Approach:deep learning· 2 Organism:human· 2

Frequent Co-Authors

A. Steen· 2 shared E. Van der Giessen· 2 shared H. Jafarinia· 2 shared J. C. Wolters· 2 shared A. Fragasso· 1 shared A. Raasakka· 1 shared C. Dekker· 1 shared E. O. van der Sluis· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

A. Steen

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7 papers

Recent·Most cited

Selective phase separation of transcription factors is driven by orthogonal molecular grammar

M. D. Driver, P. R. Onck

This study identifies orthogonal molecular forces driving selective phase separation of transcription factors and shows how RNA polymerase coalesces with these condensates to regulate transcription.

bioRxiv · Apr 12, 2024Biophysics

Structural properties of the HNF-1A transactivation domain

L. Kind, M. Driver, A. Raasakka, P. R. Onck, P. R. Njolstad, T. Arnesen, P. Kursula

The paper characterizes the disordered structure and functional properties of the HNF-1A transactivation domain using bioinformatics and biophysical methods.

bioRxiv · Jun 23, 2023Biochemistry

Tertiary structure and conformational dynamics of the anti-amyloidogenic chaperone DNAJB6b at atomistic resolution

V. Adupa, E. Ustyantseva, H. H. Kampinga, P. R. Onck

This study reveals the tertiary structure and conformational dynamics of DNAJB6b at atomistic resolution, showing it cycles between three states and has an autoinhibitory mechanism linked to disease mutations.

bioRxiv · Jun 15, 2023Biophysics

Nucleoporin Nsp1 surveils the phase state of FG-Nups

T. A. Otto, T. Bergsma, M. Dekker, S. Mouton, P. Gallardo, J. C. Wolters, A. Steen, P. R. Onck, L. L. Veenhoff

The paper shows that Nsp1 modulates FG-Nup phase separation and its loss mimics aging phenotypes in yeast.

bioRxiv · Mar 31, 2023Cell Biology

Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors

H. Jafarinia, E. Van der Giessen, P. R. Onck

This study uses molecular dynamics simulations to show how poly-PR from C9orf72 repeat expansions interacts with Kap{beta} proteins, affecting nucleocytoplasmic transport.

bioRxiv · May 5, 2022Biophysics

Nuclear transport under stress phenocopies transport defects in models of C9Orf72 ALS

M. F. Semmelink, H. Jafarinia, J. C. Wolters, T. Gheorghe, S. N. Mouton, A. Steen, P. R. Onck, L. M. Veenhoff

This study shows polyPR directly affects nuclear transport via NTRs, while polyGA impacts cellular energy state, leading to similar transport defects as stress conditions.

bioRxiv · Apr 13, 2022 · PreprintCell Biology

A designer FG-Nup that reconstitutes the selective transport barrier of the Nuclear Pore Complex

A. Fragasso, H. W. de Vries, E. O. van der Sluis, E. van der Giessen, P. R. Onck, C. Dekker

This study designs an artificial FG-Nup that mimics natural Nups and demonstrates selective transport behavior similar to native NPCs.

Nature Communications · Mar 31, 2021Peer-reviewedBiophysics