Nuclear transport under stress phenocopies transport defects in models of C9Orf72 ALS
M. F. Semmelink, H. Jafarinia, J. C. Wolters, T. Gheorghe, S. N. Mouton, A. Steen, P. R. Onck, L. M. Veenhoff
This study shows polyPR directly affects nuclear transport via NTRs, while polyGA impacts cellular energy state, leading to similar transport defects as stress conditions.
bioRxiv · Apr 13, 2022 · PreprintCell Biology