Author

H. Jafarinia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:yeast· 1

Frequent Co-Authors

E. Van der Giessen· 3 shared P. Onck· 2 shared P. R. Onck· 2 shared A. Steen· 1 shared J. C. Wolters· 1 shared L. M. Veenhoff· 1 shared M. F. Semmelink· 1 shared S. N. Mouton· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

E. Van der Giessen

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Author profile →

4 papers

Recent·Most cited

C9orf72 polyPR directly binds to various nuclear transport components

H. Jafarinia, E. Van der Giessen, P. Onck

This study investigates how polyPR, a toxic DPR from C9orf72, directly interacts with nuclear transport components, revealing potential mechanisms of NCT disruption in C9orf72-ALS.

bioRxiv · Jun 22, 2023Biophysics

Molecular basis of C9orf72 poly-PR interference with the β-karyopherin family of nuclear transport receptors

H. Jafarinia, E. Van der Giessen, P. R. Onck

This study uses molecular dynamics simulations to show how poly-PR from C9orf72 repeat expansions interacts with Kap{beta} proteins, affecting nucleocytoplasmic transport.

bioRxiv · May 5, 2022Biophysics

Nuclear transport under stress phenocopies transport defects in models of C9Orf72 ALS

M. F. Semmelink, H. Jafarinia, J. C. Wolters, T. Gheorghe, S. N. Mouton, A. Steen, P. R. Onck, L. M. Veenhoff

This study shows polyPR directly affects nuclear transport via NTRs, while polyGA impacts cellular energy state, leading to similar transport defects as stress conditions.

bioRxiv · Apr 13, 2022 · PreprintCell Biology

Phase separation of toxic dipeptide repeat proteins related to C9orf72 ALS/FTD

H. Jafarinia, E. van der Giessen, P. Onck

This study uses a molecular dynamics model to show that DPR length and concentration affect phase separation, with critical lengths matching toxicity thresholds in ALS/FTD.

Biophysical Journal · Aug 1, 2020Peer-reviewedBiophysics