3D environment promotes persistent changes in lamin B1 distribution, the biomechanical signature of the nucleus, and adaptative survival and migratory functions.
R. Gonzalez-Novo, H. Zamora Carreras, A. De Lope-Planelles, H. Lopez-Menendez, p. Roda-Navarro, F. Monroy, L. Wang, C. P. Toseland, J. Redondo-Munoz
The paper shows that 3D environments cause persistent nuclear changes, including lamin B1 distribution and mechanical behavior, affecting cell survival and migration.
bioRxiv · Apr 10, 2023 · PreprintCell Biology