J. Redondo-Munoz

Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

3D environment promotes persistent changes in lamin B1 distribution, the biomechanical signature of the nucleus, and adaptative survival and migratory functions.

The paper shows that 3D environments cause persistent nuclear changes, including lamin B1 distribution and mechanical behavior, affecting cell survival and migration.

Persistent confined migration confers permanent nuclear and functional changes in migrating cells.

The paper shows that persistent confined migration causes permanent nuclear and functional changes in cells, including lamin B1 redistribution and altered DNA repair.

Targeting H3K4 methylation as a novel therapeutic strategy against tumor infiltration and nuclear changes of acute lymphoblastic leukemia cells.

This study shows that targeting H3K4 methylation via WDR5 inhibition reduces leukemia cell invasion in vitro and tissue infiltration in vivo, revealing a novel therapeutic strategy for acute lymphoblastic leukemia.