Author

P. Simmler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

G. Schwank· 2 shared M. Stoffel· 2 shared A. Khales· 1 shared A. Vukolic· 1 shared C. Cortijo· 1 shared C. Hirt· 1 shared C. Mueller· 1 shared C. Pauli· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

G. Schwank

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2 papers

Recent·Most cited

Mutant SF3B1 promotes PDAC malignancy through TGF-β resistance

P. Simmler, T. Mengis, K. Van-Lehmann, A. Khales, T. Thomas, G. Rätsch, M. Stoffel, G. Schwank

This study shows that SF3B1K700E mutation in PDAC enhances tumor aggressiveness when combined with KRAS and p53 mutations by promoting TGF-β resistance.

bioRxiv · Jun 16, 2022Cancer Biology

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α

P. Simmler, C. Cortijo, L. M. Koch, P. Galliker, M. Schaefer, S. Angori, H. A. Bolck, C. Mueller, A. Vukolic, P. Mirtschink, Y. Christinat, N. R. Davidson, K.-V. Lehmann, G. Pellegrini, C. Pauli, , G. Schwank

This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.

bioRxiv · Nov 10, 2020Cell Biology