N. Iyer

Metabolic immaturity of newborns and breast milk bile acids are the central determinants of heightened neonatal vulnerability to norovirus diarrhea

This study identifies metabolic immaturity in newborns and maternal bile acids in breast milk as key factors increasing vulnerability to norovirus diarrhea.

cMYC-mediated immune repression is reversed by inhibition of H3K9/H3K27 methylation maintenance

This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.

ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension

This study identifies ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension and shows that the antibiotic CTC inhibits this pathway.

Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinoma

This study identifies HMOX1-expressing omental macrophages as a therapeutic target and biomarker for poor prognosis ovarian high-grade serous carcinoma.

Isolated Grauer's gorilla populations differ in diet and gut microbiome

The study examines diet and gut microbiome differences in three isolated Grauer's gorilla populations, finding population-specific profiles and co-variation between diet and microbiome.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18

This study shows that vitamin A signaling in intestinal epithelial cells enhances resistance to Salmonella infection by promoting IL-18 production, which drives epithelial cell shedding and immune cell IFN-gamma production.

A three-dimensional culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction and disease modeling

This paper introduces a 3D co-culture model of human skeletal muscle and motor neurons to study adult neuromuscular junction development and disease, showing increased receptor upregulation and disease modeling capability.