Author

E. Sutherland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

C. M. Czekster· 3 shared A. Crowe· 1 shared A. D. Bonaccorso· 1 shared A. Kumar· 1 shared B. E. Bode· 1 shared C. C. Berry· 1 shared C. J. Harding· 1 shared C. J. Leo· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

C. M. Czekster

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament

E. Sutherland, C. J. Harding, T. M. Y. D. Monceau De Bergendal, G. J. Florence, K. Ackermann, B. E. Bode, S. Synowksy, R. Sundaramoorthy, C. M. Czekster

This study characterizes the structure and mechanism of NdasCDO, a flavin-dependent cyclodipeptide oxidase, revealing its promiscuous substrate scope and reaction mechanism.

bioRxiv · Jul 24, 2024Biochemistry

Overcoming the challenges of cascade reactions and complex substrates in natural product biocatalysis: Immobilization of a cyclodipeptide synthase.

L. Alvarado-Ramirez, E. Sutherland, E. M. Melchor-Martinez, R. Parra-Saldivar, A. D. Bonaccorso, C. M. Czekster

This paper immobilizes a cyclodipeptide synthase on three supports to enable stable, recyclable production of the cyclic dipeptide cHE, demonstrating the feasibility of using immobilized enzymes with complex substrates.

bioRxiv · Jul 24, 2024 · PreprintBiochemistry

Structure, dynamics, and inhibition of Staphylococcus aureus m1A22-tRNA methyltransferase

P. Sweeney, A. Crowe, A. Kumar, D. Raju, N. B. Krishna, E. Sutherland, C. J. Leo, G. Fisher, R. Lalitha, L. Muthuraj, G. Sigamani, V. Oehler, S. Synowsky, S. L. Shirran, T. M. Gloster, , R. G. da Silva

This study characterizes the structure, dynamics, and inhibition of Staphylococcus aureus TrmK, identifying a cryptic binding pocket for drug discovery.

bioRxiv · Dec 24, 2021 · PreprintBiochemistry

Temporal differentiation of bovine airway epithelial cells grown at an air-liquid interface

D. Cozens, E. Sutherland, F. Marchesi, G. Taylor, C. C. Berry, R. L. Davies

This study characterizes a bovine airway epithelial cell model grown at an air-liquid interface, showing it becomes fully differentiated by day 21 and remains stable for three weeks.

bioRxiv · Oct 3, 2017Microbiology