J. W. Raff

Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes

The paper shows that Spd-2 recruits Polo and Aurora A to form two distinct scaffolds, Cnn-scaffold and TACC-scaffold, which are essential for mitotic centrosome assembly in Drosophila.

Cdk/Cyclin activity helps set mitotic centrosome size by influencing the centrosome growth rate and growth period

The paper shows that Cdk/Cyclin activity regulates mitotic centrosome size by modulating growth rate and period in Drosophila embryos.

A simple Turing reaction-diffusion model can explain how mother centrioles break symmetry to generate a single daughter

The paper proposes a Turing reaction-diffusion model to explain how PLK4 breaks symmetry to generate a single daughter centriole.

Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal-end

The paper shows that CP110 and Cep97 at the distal end of centrioles influence cartwheel growth at the proximal end through interactions with Plk4 oscillations.

Centriole growth is not limited by a finite pool of components, but is limited by the Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL

The paper shows that centriole growth in Drosophila embryos is not limited by component availability but by Cdk1/Cyclin-dependent phosphorylation of Ana2/STIL, which regulates growth timing.

An autonomous oscillator times and executes centriole biogenesis

The paper identifies an autonomous Plk4 oscillator at the base of growing centrioles in Drosophila embryos that times and sets centriole biogenesis duration, independent of the cell cycle.

A positive feedback loop drives centrosome maturation in flies

The paper identifies a positive feedback loop involving Spd-2, Polo, and Cnn that drives centrosome maturation in flies by enabling scaffold expansion.