Author

P. V. Sauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Assay:cryo-EM· 3 Assay:ChIP-seq· 2 Research Focus:protein structure prediction· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Nogales· 5 shared B. J. Greber· 3 shared C. A. Kerfeld· 3 shared D. Bina· 3 shared H. Kirst· 3 shared M. Sutter· 3 shared T. Polivka· 3 shared M. A. Dominguez-Martin· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersBiochemistry

E. Nogales

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Author profile →

5 papers

Recent·Most cited

Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications

T. Cookis, A. Lydecker, P. V. Sauer, V. Kasinath, E. Nogales

The paper reveals how H3K4me3 and H3K36me3 inhibit PRC2 activity by blocking its interaction with chromatin and allosteric activators, using cryo-EM.

bioRxiv · Feb 9, 2024Biochemistry

Activation of automethylated PRC2 by dimerization on chromatin

P. V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne, O. van Ray, R. Haensel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

bioRxiv · Oct 12, 2023Biochemistry

Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes

P. V. Sauer, L. Cupellini, M. Sutter, M. Bondanza, M. A. Dominguez Martin, H. Kirst, D. Bina, A. F. Koh, A. Kotecha, B. J. Greber, E. Nogales, T. Polivka, B. Mennucci, C. A. Kerfeld

The paper reveals the structure of the OCP-PBS complex and elucidates the quantum mechanism of energy transfer during non-photochemical quenching in cyanobacteria.

bioRxiv · Sep 30, 2023Biophysics

Structures of the Cyanobacterial Phycobilisome

P. V. Sauer, M. A. Dominguez-Martin, H. Kirst, M. Sutter, D. Bina, B. J. Greber, E. Nogales, T. Polivka, C. A. Kerfeld

This paper presents cryo-EM structures of the cyanobacterial phycobilisome, revealing new conformations and regulatory mechanisms of light harvesting.

bioRxiv · Nov 15, 2021Biochemistry

Structure of the Quenched Cyanobacterial OCP-Phycobilisome Complex

M. A. Dominguez-Martin, P. V. Sauer, M. Sutter, H. Kirst, D. Bina, B. J. Greber, E. Nogales, T. Polivka, C. A. Kerfeld

The paper reports the structure of the OCP-PBS complex in cyanobacteria at 2.7 Å resolution, revealing how it mediates photoprotective quenching.

bioRxiv · Nov 15, 2021 · PreprintBiochemistry