Author

M. N. Hoehne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

O. van Ray· 2 shared P. Hunold· 2 shared R. Haensel-Hertsch· 2 shared A. Singhal· 1 shared B. Morgan· 1 shared E. Nogales· 1 shared E. Pavlenko· 1 shared G. S. Herter-Sprie· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

O. van Ray

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Activation of automethylated PRC2 by dimerization on chromatin

P. V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne, O. van Ray, R. Haensel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

bioRxiv · Oct 12, 2023Biochemistry

G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments

P. Hunold, M. N. Hoehne, M. Kiljan, O. van Ray, J. Herter, G. S. Herter-Sprie, R. Haensel-Hertsch

The paper identifies G-quadruplex DNA structures in breast cancer that non-autonomously instruct macrophage transcriptomes and epigenomes, promoting immunosuppression in the tumor microenvironment.

bioRxiv · Jan 16, 2023 · PreprintCancer Biology

Thioredoxin reductase controls the capacity of peroxiredoxins to limit mitochondrial H2O2 release

M. N. Hoehne, L. J. Jacobs, K. J. Lapacz, L. M. Murschall, T. Marker, B. Morgan, M. Fricker, V. Belousov, J. Riemer

The paper investigates mitochondrial H2O2 release in mammalian cells and finds that peroxiredoxins 1 and 2 control H2O2 gradients and handling through dynamic adaptation of thioredoxin reductase.

bioRxiv · Jul 8, 2021 · PreprintBiochemistry