Author

S. Poepsel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 4 Assay:ChIP-seq· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. Nogales· 3 shared L. C. Zirden· 2 shared V. Kasinath· 2 shared A. Singhal· 1 shared A.-M. Schaffer· 1 shared A.-S. Mägdefrau· 1 shared C. Beck· 1 shared C. Benda· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersBiophysics

E. Nogales

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Author profile →

6 papers

Recent·Most cited

Conformational plasticity of a BiP-GRP94 chaperone complex

J. C. Brenner, L. C. Zirden, Y. Almeida-Hernandez, F. Kaschani, M. Kaiser, E. Sanchez-Garcia, S. Poepsel, D. Hellerschmied

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

bioRxiv · Feb 1, 2024Biochemistry

Activation of automethylated PRC2 by dimerization on chromatin

P. V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne, O. van Ray, R. Haensel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

bioRxiv · Oct 12, 2023Biochemistry

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

R. Winkler, A.-S. Mägdefrau, E.-M. Piskor, M. Kleemann, M. Beyer, K. Linke, L. Hansen, A.-M. Schaffer, M. E. Hoffmann, S. Poepsel, F. Heyd, P. Beli, T. Möröy, S. Mahboobi, O. H. Krämer, C. Kosan

This study shows that inhibiting HDAC6 with Marbostat-100 reduces MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced B-cell lymphoma.

Oncogene · Sep 6, 2022Peer-reviewedCancer Biology

JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications

V. Kasinath, C. Beck, P. Sauer, S. Poepsel, J. Kosmatka, M. Faini, D. Toso, R. Aebersold, E. Nogales

This paper reports the cryo-EM structure of human PRC2 with cofactors JARID2 and AEBP2 bound to a nucleosome containing H2AK119ub1, revealing their roles in PRC2 activity regulation and histone modification crosstalk.

Science · Jan 22, 2021Peer-reviewedBiophysics

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

K. Finogenova, J. Bonnet, S. Poepsel, I. B. Schäfer, K. Finkl, K. Schmid, C. Litz, M. Strauss, C. Benda, J. Müller

The paper determines how PRC2 is inhibited by H3K36 methylation through cryo-EM structures and shows that H3K36 mutations impair Polycomb repression.

bioRxiv · Apr 22, 2020Biochemistry

Visualization of PRC2-Dinucleosome Interactions Leading to Epigenetic Repression

S. Poepsel, V. Kasinath, E. Nogales

The paper visualizes how PRC2 interacts with dinucleosomes to mediate epigenetic repression through cryo-EM structures.

bioRxiv · Jan 8, 2018Biophysics