Author

L. C. Zirden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Poepsel· 2 shared A. Pause· 1 shared A. Singhal· 1 shared D. Hellerschmied· 1 shared E. Nogales· 1 shared E. Pavlenko· 1 shared E. Sanchez-Garcia· 1 shared F. Kaschani· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

S. Poepsel

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Author profile →

3 papers

Recent·Most cited

Conformational plasticity of a BiP-GRP94 chaperone complex

J. C. Brenner, L. C. Zirden, Y. Almeida-Hernandez, F. Kaschani, M. Kaiser, E. Sanchez-Garcia, S. Poepsel, D. Hellerschmied

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

bioRxiv · Feb 1, 2024Biochemistry

Activation of automethylated PRC2 by dimerization on chromatin

P. V. Sauer, E. Pavlenko, T. Cookis, L. C. Zirden, J. Renn, A. Singhal, P. Hunold, M. N. Hoehne, O. van Ray, R. Haensel-Hertsch, K. Y. Sanbonmatsu, E. Nogales, S. Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

bioRxiv · Oct 12, 2023Biochemistry

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3

M. Paquette, L. El-Houjeiri, L. C. Zirden, P. Puustinen, P. Blanchette, H. Jeong, K. Dejgaard, P. M. Siegel, A. Pause

This study shows that AMPK-dependent phosphorylation of TFEB/TFE3 enhances their transcriptional activity under nutrient starvation and promotes chemoresistance in cancer.

bioRxiv · Jan 27, 2021Cancer Biology