Author

P. W. Hildebrand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

B. K. Kobilka· 2 shared D. Hilger· 2 shared A. B. Seven· 1 shared A. Beck-Sickinger· 1 shared A. Koch· 1 shared A. Schmidt· 1 shared B. Bauer· 1 shared C. M. T. Spahn· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersPharmacology & Toxicology

B. K. Kobilka

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Time-resolved cryo-EM of G protein activation by a GPCR

M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi, Y. Gao, G. Eskici, A. B. Seven, O. Panova, D. Hilger, M. Casiraghi, F. He, L. Maul, P. Gmeiner, B. K. Kobilka, P. W. Hildebrand, G. Skiniotis

This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.

bioRxiv · Mar 20, 2023Pharmacology & Toxicology

Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors

F. Pohl, F. Seufert, Y. K. Chung, D. Volke, R. Hoffmann, T. Schoneberg, T. Langenhan, P. W. Hildebrand, N. Strater

This study identifies structural determinants that confer resistance to autoproteolysis in adhesion GPCRs despite the presence of a canonical GPS motif.

bioRxiv · Mar 12, 2023Biochemistry

Structures of active melanocortin-4 receptor--Gs-protein complexes with NDP-α-MSH and setmelanotide

N. A. Heyder, G. Kleinau, D. Speck, A. Schmidt, S. Paisdzior, M. Szczepek, B. Bauer, A. Koch, M. Gallandi, D. Kwiatkowski, J. Bürger, T. Mielke, A. Beck-Sickinger, P. W. Hildebrand, C. M. T. Spahn, , P. Scheerer

The paper presents cryo-EM structures of MC4R-Gs complexes with NDP-α-MSH and setmelanotide, revealing ligand-specific interactions and activation mechanisms.

bioRxiv · Apr 22, 2021Biochemistry