Author

P. Gmeiner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Research Focus:protein structure prediction· 2 Assay:electrophysiology· 1

Frequent Co-Authors

B. K. Shoichet· 2 shared B. Kobilka· 2 shared D. Weikert· 2 shared G. Skiniotis· 2 shared H. Hubner· 2 shared H. Huebner· 2 shared A. A. Inoue· 1 shared A. Allikalt· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

B. K. Shoichet

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

L. Peri, D. Matzov, D. R. Huxley, A. Rainish, F. Fierro, L. Sapir, T. Pfeiffer, L. Waterloo, H. Huebner, D. Weikert, Y. Peleg, P. Gmeiner, P. Mccormick, M. Y. Niv, M. Shalev-Benami

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

bioRxiv · Apr 10, 2024Biochemistry

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology

Structure-based discovery of CFTR potentiators and inhibitors

F. Liu, A. L. Kaplan, J. Levring, J. Einsiedel, S. Tiedt, K. Distler, N. Omattage, I. S. Kondratov, Y. S. Moroz, H. L. Pietz, J. J. Irwin, P. Gmeiner, B. K. Shoichet, J. Chen

The paper identifies novel CFTR modulators using molecular docking, electrophysiology, cryo-EM, and medicinal chemistry, discovering potentiators and inhibitors with mid-nanomolar activity.

bioRxiv · Sep 9, 2023Biophysics

Time-resolved cryo-EM of G protein activation by a GPCR

M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi, Y. Gao, G. Eskici, A. B. Seven, O. Panova, D. Hilger, M. Casiraghi, F. He, L. Maul, P. Gmeiner, B. K. Kobilka, P. W. Hildebrand, G. Skiniotis

This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.

bioRxiv · Mar 20, 2023Pharmacology & Toxicology

Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists

H. Wang, F. Hetzer, W. Huang, Q. Qu, J. Meyerowitz, J. Kaindl, H. Huebner, G. Skiniotis, B. Kobilka, P. Gmeiner

The paper reports cryoEM structures of the μ-opioid receptor bound to biased agonists PZM21 and FH210, revealing structural basis for reduced β-arrestin recruitment and guiding development of safer analgesics.

bioRxiv · Mar 22, 2022Pharmacology & Toxicology

An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptor

J. Xu, H. Hubner, Y. Hu, X. Niu, P. Gmeiner, C. Jin, B. Kobilka

This study uses NMR to show that the PAM LY2119620 changes the structure and dynamics of M2R in both extracellular and G-protein coupling domains, stabilizing distinct conformations not seen with orthosteric agonists.

bioRxiv · Feb 14, 2021 · PreprintBiophysics