Author

P. Y. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. B. Gill· 1 shared A. Durrani· 1 shared A. Marshall· 1 shared C. Alifrangis· 1 shared C. G. Smith· 1 shared C. Massie· 1 shared C. Parkinson· 1 shared D. A. Weitz· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. B. Gill

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2 papers

Recent·Most cited

Tumorigenic epithelial clusters are less sensitive to moderate osmotic stresses due to low amounts of junctional E-cadherin

D. Mohammed, P. Y. Chan, J. J. Fredberg, D. A. Weitz

This study shows that tumorigenic epithelial clusters are less sensitive to moderate osmotic stress due to reduced E-cadherin levels, affecting their mechanical properties and migration behavior.

bioRxiv · Oct 26, 2020Biophysics

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

J. C. Wan, K. Heider, D. Gale, S. Murphy, E. Fisher, J. Morris, F. Mouliere, D. Chandrananda, A. Marshall, A. B. Gill, P. Y. Chan, E. Barker, G. Young, W. N. Cooper, I. Hudecova, , N. Rosenfeld

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

bioRxiv · Sep 11, 2019 · PreprintCancer Biology