Author

N. Rosenfeld

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:variant calling· 4 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. Heider· 4 shared C. G. Smith· 3 shared D. Gale· 3 shared I. Hudecova· 3 shared J. C. Wan· 3 shared W. N. Cooper· 3 shared D. Chandrananda· 2 shared F. Mouliere· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCancer Biology

K. Heider

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4 papers

Recent·Most cited

Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

C. M. Sauer, K. Heider, J. Belic, S. E. Boyle, J. A. Hall, D.-L. Couturier, A. An, A. Vijayaraghavan, M. A. Reinius, K. Hosking, M. Vias, N. Rosenfeld, J. D. Brenton

This study develops a method to monitor ctDNA in PDX mice using dried blood spots, enabling longitudinal tracking of disease burden and treatment response.

bioRxiv · Jan 15, 2022Cancer Biology

High-sensitivity monitoring of ctDNA by patient-specific sequencing panels and integration of variant reads

J. C. Wan, K. Heider, D. Gale, S. Murphy, E. Fisher, J. Morris, F. Mouliere, D. Chandrananda, A. Marshall, A. B. Gill, P. Y. Chan, E. Barker, G. Young, W. N. Cooper, I. Hudecova, , N. Rosenfeld

This paper introduces INVAR, a method to improve ctDNA detection sensitivity using patient-specific sequencing panels and variant read integration, achieving ppm-level detection in clinical samples.

bioRxiv · Sep 11, 2019 · PreprintCancer Biology

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

C. G. Smith, T. Moser, J. Burge, M. Eldridge, A. L. Riediger, F. Mouliere, D. Chandrananda, K. Heider, J. C. Wan, A. Y. Warren, J. Morris, I. Hudecova, W. N. Cooper, T. J. Mitchell, D. Gale, , G. D. Stewart

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

bioRxiv · Sep 11, 2019 · PreprintCancer Biology

Detection of ctDNA from dried blood spots after DNA size selection

K. Heider, J. C. Wan, J. Hall, S. Boyle, I. Hudecova, D. Gale, W. N. Cooper, P. G. Corrie, J. D. Brenton, C. G. Smith, N. Rosenfeld

This paper develops a protocol to detect ctDNA from dried blood spots using low-depth WGS and fragment size selection, showing its feasibility in human and mouse models.

bioRxiv · Sep 5, 2019Cancer Biology