Author

J. J. Fredberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 7 Organism:human· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. Y. Park· 3 shared D. A. Weitz· 3 shared J. P. Butler· 3 shared A. Vahabikashi· 2 shared D. Roblyer· 2 shared H. Wu· 2 shared J. A. Mitchel· 2 shared J. Ferruzzi· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

C. Y. Park

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex

H. Wu, Y. Shen, S. Sivagurunathan, M. S. Weber, S. A. Adam, J. H. Shin, J. J. Fredberg, O. Medalia, R. Goldman, D. A. Weitz

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

Proceedings of the National Academy of Sciences · Mar 2, 2022Peer-reviewedCell Biology

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

A. Vahabikashi, S. Sivagurunathan, F. A. S. Nicdao, Y. L. Han, C. Y. Park, X. Wong, J. R. Tran, G. G. Gundersen, K. Reddy, G. G. Luxton, M. Guo, J. J. Fredberg, Y. Zheng, S. A. Adam, R. D. Goldman

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

bioRxiv · May 12, 2021Biophysics

Stiffness Regulates Intestinal Stem Cell Fate

S. He, L. Peng, W. Kang, P. Cheung, T. Xu, M. Mana, C. Y. Park, H. Wang, S. Imada, J. O. Russell, J. Wang, R. Wang, Z. Zhou, K. Chetal, E. Stas, , N. Saeidi

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

bioRxiv · Mar 15, 2021Cell Biology

Tumorigenic epithelial clusters are less sensitive to moderate osmotic stresses due to low amounts of junctional E-cadherin

D. Mohammed, P. Y. Chan, J. J. Fredberg, D. A. Weitz

This study shows that tumorigenic epithelial clusters are less sensitive to moderate osmotic stress due to reduced E-cadherin levels, affecting their mechanical properties and migration behavior.

bioRxiv · Oct 26, 2020Biophysics

Epithelial layer unjamming shifts energy metabolism toward glycolysis

S. J. DeCamp, V. M. K. Tsuda, J. Ferruzzi, S. A. Koehler, D. Roblyer, J. T. Giblin, M. H. Zaman, S. T. Weiss, M. DeMarzio, C. Y. Park, N. C. Ogassavara, J. A. Mitchel, J. P. Butler, J. J. Fredberg

The paper shows that during epithelial layer unjamming, cells shift their metabolism toward glycolysis, even in regions without visible morphological changes.

bioRxiv · Jun 30, 2020Biophysics

Tumor invasion as non-equilibrium phase separation

W. Kang, J. Ferruzzi, C.-P. Spatarelu, Y. L. Han, Y. Sharma, S. Koehler, J. P. Butler, D. Roblyer, M. H. Zaman, M. Guo, Z. Chen, A. F. Pegoraro, J. J. Fredberg

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

bioRxiv · Apr 28, 2020 · PreprintBiophysics

The unjamming transition is distinct from the epithelial-to-mesenchymal transition.

J. A. Mitchel, A. Das, M. J. O'Sullivan, I. T. Stancil, S. J. DeCamp, S. Koehler, J. P. Butler, J. J. Fredberg, M. A. Nieto, D. Bi, J.-A. Park

This paper distinguishes the unjamming transition (UJT) from the epithelial-to-mesenchymal transition (EMT) by showing UJT enables collective epithelial migration without EMT features.

bioRxiv · Jun 10, 2019 · PreprintBiophysics

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

A. Vahabikashi, C. Young Park, K. Perkumas, Z. Zhang, E. K. Deurloo, H. Wu, D. A. Weitz, W. D. Stamer, R. D. Goldman, J. J. Fredberg, M. Johnson

The paper compares the sensitivity of four probe technologies to measure biomechanical properties of different cellular regions in two cell types under various perturbations.

bioRxiv · Oct 16, 2018Biophysics