P. Yao

Novel Imaging Tools to Study Mitochondrial Dynamics in Caenorhabditis elegans

The paper introduces novel genetic tools for live imaging of mitochondrial networks in C. elegans and compares them with existing methods, highlighting their advantages and limitations.

Cardiomyocyte-specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy

This study shows that loss of EPRS1 in cardiomyocytes causes dilated cardiomyopathy and heart failure, with altered protein homeostasis and metabolic pathways.

Spatiotemporal development of growth and death zones in expanding bacterial colonies driven by emergent nutrient dynamics

This study shows that bacterial colony expansion is driven by mechanical constraints and nutrient gradients, with cell death occurring in a distinct zone due to glucose depletion and anaerobiosis.

Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli

This study develops a method to purify human FAM210A, a mitochondrial transmembrane protein, using E. coli and validates its interaction with EF-Tu.

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

This study identifies FAM210A as a regulator of mitochondrial translation and cardiac mitochondrial homeostasis, showing its deficiency leads to heart failure and its overexpression rescues cardiac function in ischemic heart disease.

FAM114A1 Influences Cardiac Fibrosis by Regulating Angiotensin II Signaling in Cardiac Fibroblasts

This study identifies FAM114A1 as a regulator of cardiac fibrosis by modulating Ang II signaling in cardiac fibroblasts, showing its role in fibrosis and potential as a therapeutic target.

High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA

The paper investigates immune responses and parasite phenotypes in naturally infected cynomolgus macaques, revealing diverse parasite genetic types and immune profiles despite uniform housing conditions.

MicroRNA-574 Regulates FAM210A Expression and Influences Pathological Cardiac Remodeling

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

EPRS Regulates Proline-rich Pro-fibrotic Protein Synthesis during Cardiac Fibrosis

This study identifies EPRS as a key regulator of proline-rich pro-fibrotic gene translation in cardiac fibrosis, showing its role in promoting fibrosis and identifying potential therapeutic targets.