Identification of novel cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile
Paul J. Hensbergen, Bob van Puffelen, Nina Musch, Augustinus N. A. Ammerlaan, P. Zuidgeest, Loes van Huijkelom, Rembrandt J.V. Kanbier, Maaike M. Vet, Xuan S. Zheng, Pranav V.N. Bhamidipati, Martin F. Larralde, Niek Blomberg, Sarantos Kostidis, Peter A. van Veelen, Robert A. Cordfunke, , Jeroen Corver
This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.
Proceedings of the National Academy of Sciences · Jul 7, 2026Peer-reviewedMicrobiology