Author

Niek Blomberg

Leiden University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:metabolomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Martin A. GieraiD· 4 shared Rik van der KantiD· 3 shared Adrian M. IsaacsiD· 2 shared Alexander J. CammackiD· 2 shared Ashling GibliniD· 2 shared Damien Olivier‐JimeneziD· 2 shared Sascha Koppes-den HertogiD· 2 shared Tammaryn LashleyiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Martin A. GieraORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

APOE genotypes differentially remodel the astrocytic lipiddroplet-associated proteome to shape lipid droplet dynamics

Carla Cuní‐López, Jessica T. Root, Ying Hao, Niek Blomberg, Sascha Koppes-den Hertog, Dylan C. Sacks, Amber E. Trujillo, Rodolfo Ghirlando, Isabelle Kowal, Jacob Epstein, Linda G. Yang, Mark Cookson, Elise Marsan, Rik van der Kant, Martin A. Giera, , Priyanka S. Narayan

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

Nature Communications · Aug 19, 2026Peer-reviewedCell Biology

Identification of novel cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in Clostridioides difficile

Paul J. Hensbergen, Bob van Puffelen, Nina Musch, Augustinus N. A. Ammerlaan, P. Zuidgeest, Loes van Huijkelom, Rembrandt J.V. Kanbier, Maaike M. Vet, Xuan S. Zheng, Pranav V.N. Bhamidipati, Martin F. Larralde, Niek Blomberg, Sarantos Kostidis, Peter A. van Veelen, Robert A. Cordfunke, , Jeroen Corver

This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.

Proceedings of the National Academy of Sciences · Jul 7, 2026Peer-reviewedMicrobiology

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

Femke M. Feringa, Sascha Koppes-den Hertog, Lian Y. Wang, Rico J. E. Derks, Iris Daphne Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier‐Jimenez, Lill Eva Johansen, Alexander J. Cammack, Ashling Giblin, Christina E. Toomey, , Rik van der Kant

The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.

Nature Metabolism · Sep 22, 2025Peer-reviewedNeuroscience

Neuronal polyunsaturated fatty acids are protective in FTD/ALS

Ashling Giblin, Alexander J. Cammack, Niek Blomberg, Sharifah Anoar, Alla Mikheenko, Mireia Carcolé, Magda Luciana Atilano, Alexander J. Hull, Dunxin Shen, Xiao‐Ya Wei, Rachel Coneys, Lele Zhou, Yassene Mohammed, Damien Olivier‐Jimenez, Lian Y. Wang, , Adrian M. Isaacs

The paper identifies reduced PUFA levels in FTD/ALS models and shows neuronal PUFA supplementation improves survival and reduces neuronal death.

Nature Neuroscience · Feb 25, 2025Peer-reviewedNeuroscience