Arnoud H. de Ru

The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.

This study identifies two novel biosynthetic intermediates and characterizes their enzymes in the unique glycan modification pathway of C. difficile flagellin.

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

This study identifies VAPB and AKAP11 as regulators of lipid droplet homeostasis by mediating neutral lipid degradation through membrane contact sites and PKA activity.

This study uses patient-derived organoids to analyze glycosylation changes in gastric tissues and shows they mimic in vivo glycosylation profiles and H. pylori interactions.

This study identifies the unknown moiety in the b-type flagellin glycan of Pseudomonas aeruginosa PAO1 as N,N-dimethylthreonine using mass spectrometry and compares it to Type A glycan in C. difficile.

This study shows that vault RNAs enhance viral replication by facilitating the nuclear export of ELAVL1 and hnRNP C, which are required for efficient viral replication.

This study shows that HtrA proteolytic activity affects its expression level and is necessary for C. difficile survival under acidic conditions.

The paper identifies PCNA as a substrate of BRCA1/BARD1 ubiquitin E3 activity, showing it promotes replication fork stability and continuous DNA synthesis without requiring Homologous Recomberation or Olaparib resistance.

The paper characterizes the non-prime- and prime-side specificity of Pro-Pro endopeptidases using synthetic peptide libraries and mass spectrometry, identifying novel PPEPs and altered specificity in mutants.

The paper introduces SATTs to identify E3-specific SUMO substrates, finding 1681 SUMO substrates across eight E3s with distinct preferences.