Synthesis and In Vitro Characterization of OGA-2506 as a High Affinity Radioligand for O-GlcNAcase
Yinlong Li, Taoqian Zhao, Zhendong Song, Xin Mu Zhou, Pablo Martinez Pardo, Jiahui Chen, Qi-Long Hu, Chongjiao Li, Xiaoyan Li, Zhenkun Sun, Yabiao Gao, Danielle E. Hoyle, Jimmy S. Patel, Charles S. Elmore, Hongjie Yuan, Steven H. Liang
The paper reports the synthesis of a high-affinity radioligand for O-GlcNAcase and its in vitro characterization.
bioRxiv · Sep 19, 2025 · PreprintPharmacology & Toxicology