This paper evaluates [18F]AZD9574, a PET radiotracer for imaging PARP-1, showing uptake correlated with PARP-1 expression and blocked by PARP inhibitors in cancer cell lines and xenograft models.

bioRxiv · Nov 1, 2025 · PreprintCancer Biology

Plant coumarins enhance viral pathogenicity by miRNA-mediated apoptosis in insect herbivores

Jinyan Wang, Hao Zhang, Yuan Yuan, Mark A. Hanson, Wen-Li Xia, Jun-Xiang Zhou, Zhendong Song, Jie‐Xian Jiang, Xiang‐Yun Ji, Nian‐Feng Wan

The paper shows plant coumarins increase NPV-induced apoptosis in insect larvae via miRNA regulation, enhancing viral pathogenicity.

bioRxiv · Sep 29, 2025 · PreprintEcology

Synthesis and In Vitro Characterization of OGA-2506 as a High Affinity Radioligand for O-GlcNAcase

Yinlong Li, Taoqian Zhao, Zhendong Song, Xin Mu Zhou, Pablo Martinez Pardo, Jiahui Chen, Qi-Long Hu, Chongjiao Li, Xiaoyan Li, Zhenkun Sun, Yabiao Gao, Danielle E. Hoyle, Jimmy S. Patel, Charles S. Elmore, Hongjie Yuan, Steven H. Liang

The paper reports the synthesis of a high-affinity radioligand for O-GlcNAcase and its in vitro characterization.

bioRxiv · Sep 19, 2025 · PreprintPharmacology & Toxicology

Preclinical Evaluation of P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging

Zhendong Song, Yinlong Li, Siyan Feng, Jiahui Chen, Xin Mu Zhou, Zhixu Zhang, Zhenkun Sun, Jian Rong, Chunyu Zhao, Ahmad F. Chaudhary, Jimmy S. Patel, Yabiao Gao, Thomas Lee Collier, Chongzhao Ran, Tyler S. Beyett, , Steven H. Liang

This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.

bioRxiv · Jan 16, 2025 · PreprintNeuroscience