Jiahui Chen

This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.

The paper designs and evaluates novel PET tracers for CYP46A1 by modifying cyclopropyl groups, showing high affinity and suitable radiosynthesis.

This paper evaluates [18F]AZD9574, a PET radiotracer for imaging PARP-1, showing uptake correlated with PARP-1 expression and blocked by PARP inhibitors in cancer cell lines and xenograft models.

The paper reports the synthesis of a high-affinity radioligand for O-GlcNAcase and its in vitro characterization.

This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.

This study investigates how GLP-1R agonists affect human hypothalamic neurons derived from pluripotent stem cells, finding they induce depolarization, increased firing, and gene expression changes.

The paper identifies over 2100 MSL proteins across 176 plants, performs phylogenetic analysis, and proposes an evolutionary model for MSL proteins in plants.

This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.