A novel 18F-labeled brain penetrant PET ligand for imaging poly(ADP-ribose) polymerase-1
Jimmy S. Patel, Xin Mu Zhou, Jiahui Chen…·Steven H. Liang
This paper evaluates [18F]AZD9574, a PET radiotracer for imaging PARP-1, showing uptake correlated with PARP-1 expression and blocked by PARP inhibitors in cancer cell lines and xenograft models.