Steven H. Liang

The paper designs and evaluates novel PET tracers for CYP46A1 by modifying cyclopropyl groups, showing high affinity and suitable radiosynthesis.

The paper discovers abundant nanoscale lymphatic-like vessels in brain parenchyma of mice and humans, suggesting a previously unrecognized system for metabolic waste clearance.

This paper evaluates [18F]AZD9574, a PET radiotracer for imaging PARP-1, showing uptake correlated with PARP-1 expression and blocked by PARP inhibitors in cancer cell lines and xenograft models.

The paper reports the synthesis of a high-affinity radioligand for O-GlcNAcase and its in vitro characterization.

This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.

This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.